Adrian T. Keatinge-Clay: search on Z-Library

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1

General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases

Zhang, Zhicheng, Cepeda, Alexis J., Robles, Mireya L., Hirsch, Melissa, Kumru, Kaan, Zhou, Jina A., Keatinge-Clay, Adrian T.

Journal:

Chemical Communications

Year:

2020

Language:

english

File:

PDF, 1.64 MB

english, 2020

2

Precursor-directed biosynthesis of 12-ethyl erythromycin

John R Jacobsen, Adrian T Keatinge-Clay, David E Cane, Chaitan Khosla

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 171 KB

english, 1998

3

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

Jianting Zheng, Clint A. Taylor, Shawn K. Piasecki, Adrian T. Keatinge-Clay

Journal:

Year:

2010

Language:

english

File:

PDF, 1.98 MB

english, 2010

4

Mechanobiochemistry: harnessing biomacromolecules for force-responsive materials

Brantley, Johnathan N., Bailey, Constance B., Wiggins, Kelly M., Keatinge-Clay, Adrian T., Bielawski, Christopher W.

Journal:

Polymer Chemistry

Year:

2013

Language:

english

File:

PDF, 1.46 MB

english, 2013

5

Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG

Isiorho, Eta A., Liu, Hung-wen, Keatinge-Clay, Adrian T.

Journal:

Year:

2012

Language:

english

File:

PDF, 6.92 MB

english, 2012

6

Divergence of multimodular polyketide synthases revealed by a didomain structure

Zheng, Jianting, Gay, Darren C, Demeler, Borries, White, Mark A, Keatinge-Clay, Adrian T

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.92 MB

english, 2012

7

Mechanically Modulating the Photophysical Properties of Fluorescent Protein Biocomposites for Ratio- and Intensiometric Sensors

Brantley, Johnathan N., Bailey, Constance B., Cannon, Joe R., Clark, Katie A., Vanden Bout, David A., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T., Bielawski, Christopher W.

Journal:

Angewandte Chemie

Year:

2014

Language:

english

File:

PDF, 947 KB

english, 2014

8

Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase

Adrian T. Keatinge-Clay, Anang A. Shelat, David F. Savage, Shiou-Chuan Tsai, Larry J.W. Miercke, Joseph D. O'Connell III, Chaitan Khosla, Robert M. Stroud

Journal:

Year:

2003

Language:

english

File:

PDF, 654 KB

english, 2003

9

Structure and Stereospecificity of the Dehydratase Domain from the Terminal Module of the Rifamycin Polyketide Synthase

Gay, Darren, You, Young-Ok, Keatinge-Clay, Adrian, Cane, David E.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

10

The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition

Fage, Christopher D, Isiorho, Eta A, Liu, Yungnan, Wagner, Drew T, Liu, Hung-wen, Keatinge-Clay, Adrian T

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.64 MB

english, 2015

11

Monitoring Biocatalytic Transformations Mediated by Polyketide Synthase Enzymes in Cell Lysate via Fluorine NMR

Piasecki, Shawn, Keatinge-Clay, Adrian

Journal:

Year:

2012

Language:

english

File:

PDF, 324 KB

english, 2012

12

Preparative, in Vitro Biocatalysis of Triketide Lactone Chiral Building Blocks

Andrew D. Harper, Constance B. Bailey, Angela D. Edwards, Joshua F. Detelich, Prof. Adrian T. Keatinge-Clay

Journal:

Year:

2012

Language:

english

File:

PDF, 484 KB

english, 2012

13

Structural Studies of the Spinosyn Forosaminyltransferase, SpnP

Isiorho, Eta A., Jeon, Byung-Sun, Kim, Nam Ho, Liu, Hung-wen, Keatinge-Clay, Adrian T.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.00 MB

english, 2014

14

Substrate structure–activity relationships guide rational engineering of modular polyketide synthase ketoreductases

Bailey, Constance B., Pasman, Marjolein E., Keatinge-Clay, Adrian T.

Journal:

Chemical Communications

Year:

2016

Language:

english

File:

PDF, 1.71 MB

english, 2016

15

Employing Modular Polyketide Synthase Ketoreductases as Biocatalysts in the Preparative Chemoenzymatic Syntheses of Diketide Chiral Building Blocks

Shawn K. Piasecki, Clint A. Taylor, Joshua F. Detelich, June Liu, Jianting Zheng, Arkady Komsoukaniants, Dionicio R. Siegel, Adrian T. Keatinge-Clay

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

16

The structures of type I polyketide synthases

Keatinge-Clay, Adrian T.

Journal:

Natural Product Reports

Year:

2012

Language:

english

File:

PDF, 2.78 MB

english, 2012

17

The Structure of a Ketoreductase Determines the Organization of the β-Carbon Processing Enzymes of Modular Polyketide Synthases

Adrian T. Keatinge-Clay, Robert M. Stroud

Journal:

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

18

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

Zheng, Jianting, Piasecki, Shawn K., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 3.14 MB

english, 2013

19

Structural and Functional Analysis of C2-Type Ketoreductases from Modular Polyketide Synthases

Jianting Zheng, Adrian T. Keatinge-Clay

Journal:

Journal of Molecular Biology

Year:

2011

Language:

english

File:

PDF, 1.95 MB

english, 2011

20

Antimicrobial Peptide Resistance of Vibrio cholerae Results from an LPS Modification Pathway Related to Nonribosomal Peptide Synthetases

Henderson, Jeremy C., Fage, Christopher D., Cannon, Joe R., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T., Trent, M. Stephen

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 5.78 MB

english, 2014

21

High-Resolution Macromolecular NMR Spectroscopy Inside Living Cells

Serber, Zach, Keatinge-Clay, Adrian T., Ledwidge, Richard, Kelly, Alexander E., Miller, Susan M., Dötsch, Volker

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 28 KB

english, 2001

22

Structural and Functional Trends in Dehydrating Bimodules from trans -Acyltransferase Polyketide Synthases

Wagner, Drew T., Zeng, Jia, Bailey, Constance B., Gay, Darren C., Yuan, Fang, Manion, Hannah R., Keatinge-Clay, Adrian T.

Journal:

Year:

2017

Language:

english

File:

PDF, 4.07 MB

english, 2017

23

Polyketide Synthase Modules Redefined

Keatinge-Clay, Adrian T.

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.74 MB

english, 2017

24

Stereocontrol within polyketide assembly lines

Keatinge-Clay, Adrian T.

Journal:

Natural Product Reports

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

25

Portability and Structure of the Four-Helix Bundle Docking Domains of trans -Acyltransferase Modular Polyketide Synthases

Zeng, Jia, Wagner, Drew T., Zhang, Zhicheng, Moretto, Luisa, Addison, Janci D., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.72 MB

english, 2016

26

A Tylosin Ketoreductase Reveals How Chirality Is Determined in Polyketides

Adrian T. Keatinge-Clay

Journal:

Chemistry & Biology

Year:

2007

Language:

english

File:

PDF, 1.89 MB

english, 2007

27

A Double-Hotdog with a New Trick: Structure and Mechanism of the trans -Acyltransferase Polyketide Synthase Enoyl-isomerase

Gay, Darren C., Spear, Philip J., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2014

Language:

english

File:

PDF, 3.67 MB

english, 2014

28

An antibiotic factory caught in action

Keatinge-Clay, Adrian T, Maltby, David A, Medzihradszky, Katalin F, Khosla, Chaitan, Stroud, Robert M

Journal:

Nature Structural and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.07 MB

english, 2004

29

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

Adrian Keatinge-Clay

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 3.78 MB

english, 2008

30

Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors

Meinke, Jessica L, Simon, Anna J., Wagner, Drew T, Morrow, Barrett R, You, Shaochen, Ellington, Andrew D., Keatinge-Clay, Adrian T

Journal:

ACS Synthetic Biology

Year:

2019

Language:

english

File:

PDF, 1.17 MB

english, 2019

31

Crystal Structure of the Priming β-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway

Hu Pan, Shiou-chuan Tsai, Eric S. Meadows, Larry J.W. Miercke, Adrian T. Keatinge-Clay, Joe O'Connell, Chaitan Khosla, Robert M. Stroud

Journal:

Year:

2002

Language:

english

File:

PDF, 2.00 MB

english, 2002

32

Rapid modification of the pET-28 expression vector for ligation independent cloning using homologous recombination in Saccharomyces cerevisiae

Gay, Glen, Wagner, Drew T., Keatinge-Clay, Adrian T., Gay, Darren C.

Journal:

Year:

2014

Language:

english

File:

PDF, 709 KB

english, 2014

33

The Structural Relationship between Iterative and Modular PKSs

Keatinge-Clay, Adrian T.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

34

Substrate-bound Structures of a Ketoreductase from Amphotericin Modular Polyketide Synthase

Liu, Chenguang, Yuan, Meijuan, Xu, Xu, Wang, Lei, Keatinge-Clay, Adrian T., Deng, Zixin, Lin, Shuangjun, Zheng, Jianting

Journal:

Journal of Structural Biology

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

35

Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Func-tional Showcasing of Streptomyces coelicolor MatB

Amanda J. Hughes, Adrian Keatinge-Clay

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 1.65 MB

english, 2011

36

Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni

Fage, Christopher D., Brown, Dusty B., Boll, Joseph M., Keatinge-Clay, Adrian T., Trent, M. Stephen

Journal:

Acta Crystallographica Section D Biological Crystallography

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

37

Stereospecificity of the Dehydratase Domain of the Erythromycin Polyketide Synthase

Valenzano, Chiara R., You, Young-Ok, Garg, Ashish, Keatinge-Clay, Adrian, Khosla, Chaitan, Cane, David E.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 165 KB

english, 2010

38

Molecular Dynamics Studies of Modular Polyketide Synthase Ketoreductase Stereospecificity

Mugnai, Mauro L., Shi, Yue, Keatinge-Clay, Adrian T., Elber, Ron

Journal:

Year:

2015

Language:

english

File:

PDF, 3.13 MB

english, 2015

39

Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous β-ketoacyl thiolase from Ralstonia eutropha

Fage, Christopher D., Meinke, Jessica L., Keatinge-Clay, Adrian T.

Journal:

Journal of Molecular Catalysis B: Enzymatic

Year:

2015

Language:

english

File:

PDF, 5.56 MB

english, 2015

40

Polyketidsynthase-Module: eine Neudefinition

Keatinge-Clay, Adrian T.

Journal:

Angewandte Chemie

Year:

2017

Language:

german

File:

PDF, 1.98 MB

german, 2017

41

General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases

Zhang, Zhicheng, Cepeda, Alexis J., Robles, Mireya L., Hirsch, Melissa, Kumru, Kaan, Zhou, Jina A., Keatinge-Clay, Adrian T.

Journal:

Chemical Communications

Year:

2020

File:

PDF, 1.64 MB

2020

42

α-Methylation follows condensation in the gephyronic acid modular polyketide synthase

Wagner, Drew T., Stevens, D. Cole, Mehaffey, M. Rachel, Manion, Hannah R., Taylor, Richard E., Brodbelt, Jennifer S., Keatinge-Clay, Adrian T.

Journal:

Chemical Communications

Year:

2016

Language:

english

File:

PDF, 2.39 MB

english, 2016

43

Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones

Hughes, Amanda J., Detelich, Joshua F., Keatinge-Clay, Adrian T.

Journal:

Year:

2012

Language:

english

File:

PDF, 730 KB

english, 2012

44

The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex

Gay, Darren C., Wagner, Drew T., Meinke, Jessica L., Zogzas, Charles E., Gay, Glen R., Keatinge-Clay, Adrian T.

Journal:

Journal of Structural Biology

Year:

2015

Language:

english

File:

PDF, 2.73 MB

english, 2015

45

A Close Look at a Ketosynthase from a Trans-Acyltransferase Modular Polyketide Synthase

Gay, Darren C., Gay, Glen, Axelrod, Abram J., Jenner, Matthew, Kohlhaas, Christoph, Kampa, Annette, Oldham, Neil J., Piel, Jörn, Keatinge-Clay, Adrian T.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.32 MB

english, 2014

46

Structure of Salmonella FlhE, Conserved Member of a Flagellar Type III Secretion Operon

Lee, Jaemin, Monzingo, Arthur F., Keatinge-Clay, Adrian T., Harshey, Rasika M.

Journal:

Journal of Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

47

Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues

Xie, Xinqiang, Garg, Ashish, Keatinge-Clay, Adrian T., Khosla, Chaitan, Cane, David E.

Journal:

Year:

2016

Language:

english

File:

PDF, 2.48 MB

english, 2016

48

The Modules of trans -Acyltransferase Assembly Lines Redefined with a Central Acyl Carrier Protein

Vander Wood, Drew A., Keatinge-Clay, Adrian T.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2018

Language:

english

File:

PDF, 2.02 MB

english, 2018

49

The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules

Zheng, Jianting, Fage, Christopher D., Demeler, Borries, Hoffman, David W., Keatinge-Clay, Adrian T.

Journal:

ACS Chemical Biology

Year:

2013

Language:

english

File:

PDF, 1.38 MB

english, 2013

50

Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase

Castonguay, Roselyne, Valenzano, Chiara R., Chen, Alice Y., Keatinge-Clay, Adrian, Khosla, Chaitan, Cane, David E.

Journal:

Journal of the American Chemical Society

Year:

2008

Language:

english

File:

PDF, 324 KB

english, 2008

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